diff --git a/.azuredevops/rocm-ci-mainline.yml b/.azuredevops/rocm-ci-mainline.yml
new file mode 100644
index 0000000000..042e985b8a
--- /dev/null
+++ b/.azuredevops/rocm-ci-mainline.yml
@@ -0,0 +1,65 @@
+resources:
+  repositories:
+  - repository: pipelines_repo
+    type: github
+    endpoint: ROCm
+    name: ROCm/ROCm
+
+variables:
+- group: common
+- template: /.azuredevops/variables-global.yml@pipelines_repo
+
+trigger:
+  batch: true
+  branches:
+    include:
+    - amd-mainline
+  paths:
+    exclude:
+    - .github
+    - docs
+    - '.*.y*ml'
+    - '*.md'
+    - AUTHORS
+    - LICENSE
+    - VERSION
+
+pr:
+  autoCancel: true
+  branches:
+    include:
+    - amd-mainline
+  paths:
+    exclude:
+    - .github
+    - docs
+    - '.*.y*ml'
+    - '*.md'
+    - AUTHORS
+    - LICENSE
+    - VERSION
+  drafts: false
+
+# For changes to mainline, only build & test against mainline ROCm
+jobs:
+  - template: ${{ variables.CI_COMPONENT_PATH }}/rocprofiler-compute.yml@pipelines_repo
+    parameters:
+      jobMatrix:
+        buildJobs:
+          - gfx942-mainline:
+            name: gfx942_mainline
+            target: gfx942
+            dependencySource: mainline
+          - gfx90a-mainline:
+            name: gfx90a_mainline
+            target: gfx90a
+            dependencySource: mainline
+        testJobs:
+          - gfx942-mainline:
+            name: gfx942_mainline
+            target: gfx942
+            dependencySource: mainline
+          - gfx90a-mainline:
+            name: gfx90a_mainline
+            target: gfx90a
+            dependencySource: mainline
diff --git a/.azuredevops/rocm-ci.yml b/.azuredevops/rocm-ci.yml
index 3c0d1b7df0..26e4d6095a 100644
--- a/.azuredevops/rocm-ci.yml
+++ b/.azuredevops/rocm-ci.yml
@@ -15,7 +15,6 @@ trigger:
     include:
     - develop
     - amd-staging
-    - amd-mainline
   paths:
     exclude:
     - .github
@@ -32,7 +31,6 @@ pr:
     include:
     - develop
     - amd-staging
-    - amd-mainline
   paths:
     exclude:
     - .github
@@ -44,5 +42,6 @@ pr:
     - VERSION
   drafts: false
 
+# For changes to develop and staging, build & test against both staging and mainline ROCm
 jobs:
   - template: ${{ variables.CI_COMPONENT_PATH }}/rocprofiler-compute.yml@pipelines_repo