diff --git a/CMakeLists.txt b/CMakeLists.txt
index 34d26c8478..97aa9f59a7 100644
--- a/CMakeLists.txt
+++ b/CMakeLists.txt
@@ -75,7 +75,12 @@ if (BUILD_ADDRESS_SANITIZER)
   SET(amdgpu_targets "")
   foreach(amdgpu_target IN LISTS GPU_TARGETS)
     if(NOT amdgpu_target STREQUAL "")
-      list(APPEND amdgpu_targets "${amdgpu_target}:xnack+")
+      string(FIND "${amdgpu_target}" ":xnack+" HAS_XNACK_SUFFIX)
+      if(HAS_XNACK_SUFFIX EQUAL -1)
+        list(APPEND amdgpu_targets "${amdgpu_target}:xnack+")
+      else()
+        list(APPEND amdgpu_targets "${amdgpu_target}")
+      endif()
     endif()
   endforeach()
   SET(GPU_TARGETS "${amdgpu_targets}" CACHE STRING "Modified GPU list for Address-Sanitizer enabled build." FORCE)